Faculté des Sciences appliquées
Faculté des Sciences appliquées

Fabrication and investigation of nano-bio interfaces

Stoffels, Charlotte ULiège
Promotor(s) : Lambert, Stéphanie ULiège
Date of defense : 6-Sep-2018/7-Sep-2018 • Permalink :
Title : Fabrication and investigation of nano-bio interfaces
Author : Stoffels, Charlotte ULiège
Date of defense  : 6-Sep-2018/7-Sep-2018
Advisor(s) : Lambert, Stéphanie ULiège
Committee's member(s) : Grandfils, Christian ULiège
Léonard, Angélique ULiège
Krishnamoorthy, Sivashankar 
Language : English
Discipline(s) : Engineering, computing & technology > Chemical engineering
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en ingénieur civil en chimie et science des matériaux, à finalité spécialisée
Faculty: Master thesis of the Faculté des Sciences appliquées


[en] The need for production of large amount of cells in the treatment of challenging diseases such as cancer brought up the idea of expanding and proliferating anchorage-dependent cells on microbeads, called microcarriers. The development of new microcarriers to improve cell adhesion as well as process automation has been intensively studied for production of biologics and vaccines. However, cell-based therapies require the recovering of the cells after expansion and proliferation on microcarriers. Hence, the development of microcarriers allowing control cell adhesion and proliferation, as well as cell detachment without damaging the cells is currently a clear objective. Herein, we have successfully developed a technique consisting of functionalizing commercially available microcarriers in order to improve cell interaction while maintaining their bulk properties optimized for large-scale production.



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  • Stoffels, Charlotte ULiège Université de Liège > Master ingé. civil chim. & sc. mat., à fin.


Committee's member(s)

  • Grandfils, Christian ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
    ORBi View his publications on ORBi
  • Léonard, Angélique ULiège Université de Liège - ULiège > Department of Chemical Engineering > PEPs (Product, Environment, Processes)
    ORBi View his publications on ORBi
  • Krishnamoorthy, Sivashankar Luxembourg Institute of Science and Technology (LIST)
  • Total number of views 56
  • Total number of downloads 2

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