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Faculté de Médecine Vétérinaire
Faculté de Médecine Vétérinaire
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Le microbiome règne-t-il sur le cerveau des mammifères ?

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Thiriet, Clothilde ULiège
Promotor(s) : Gillet, Laurent ULiège
Date of defense : 27-Jun-2019 • Permalink : http://hdl.handle.net/2268.2/7044
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Title : Le microbiome règne-t-il sur le cerveau des mammifères ?
Translated title : [en] Does microbioma reign over mammalian brains ?
Author : Thiriet, Clothilde ULiège
Date of defense  : 27-Jun-2019
Advisor(s) : Gillet, Laurent ULiège
Committee's member(s) : Vanderplasschen, Alain ULiège
Dewals, Benjamin ULiège
Machiels, Benedicte ULiège
Boutier, Maxime ULiège
Language : French
Number of pages : 50
Keywords : [en] microbiome
[en] microbiota
[en] gut-brain axis
[en] neurodevelopment
[en] behavior
[en] stress
[en] social behavior
[en] autism spectrum disorder
[en] Parkinson’s disease
Discipline(s) : Social & behavioral sciences, psychology > Neurosciences & behavior
Target public : Researchers
Professionals of domain
Student
General public
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en médecine vétérinaire
Faculty: Master thesis of the Faculté de Médecine Vétérinaire

Abstract

[en] Every multicellular organism is colonized by microbiota - communities of bacteria, viruses, fungi, and other microorganisms - that live mutualistically in and on animals (on the skin, in mouth, vagina...). The intestinal microbiota is the most important of them. The genetic potential of the mammalian intestinal microbiota surpasses that of the host in richness and diversity. There are remarkable bi-directional associations between the brain and this true "hidden organ". These interactions have attracted increasing interest from scientists around the world over the past decade. The studies then carried out revealed compelling effects of the intestinal-brain axis and in particular intestinal microbes on mammalian behaviour and neurophysiology. In this work we discuss the impact of the microbiome on the brain function of its hosts, including the development and function of the nervous system and several complex host behaviours: emotions and stress and social behaviour. We are also interested in its potential role in a neurodevelopmental disease, autism spectrum disorder, and a neurodegenerative disease, Parkinson's disease.


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  • Thiriet, Clothilde ULiège Université de Liège > Master méd. vété.

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