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Flow formulations of active ingredient loaded particles of biodegradable (co)polymers

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Schvartzman, Clémence ULiège
Promotor(s) : Jérôme, Christine ULiège ; Lecomte, Philippe ULiège
Date of defense : 29-Jun-2020 • Permalink : http://hdl.handle.net/2268.2/9138
Details
Title : Flow formulations of active ingredient loaded particles of biodegradable (co)polymers
Author : Schvartzman, Clémence ULiège
Date of defense  : 29-Jun-2020
Advisor(s) : Jérôme, Christine ULiège
Lecomte, Philippe ULiège
Committee's member(s) : Jérôme, Christine ULiège
Lecomte, Philippe ULiège
Debuigne, Antoine ULiège
Language : English
Number of pages : 83
Keywords : [en] Microfluidic
[en] Ploy(lactide)
[en] Poly(phosphoester)
[en] Drug delivery systems
[en] Biomaterials
[en] Micro-particles
Discipline(s) : Physical, chemical, mathematical & earth Sciences > Chemistry
Research unit : CERM
Name of the research project : IN FLOW PROJECT
Target public : Researchers
Professionals of domain
Student
General public
Other
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences chimiques, à finalité approfondie
Faculty: Master thesis of the Faculté des Sciences

Abstract

[fr] This master thesis was part of the IN FLOW project which aimed to develop and introduce new (bio)degradable packaging technologies for the fast and cheap formulation of active ingredients in pills or creams for example [1]. The final objective of this work was to produce non-toxic, biocompatible and biodegradable poly(lactide)/polyphosphate with olefin terminal group particles for drug-controlled delivery systems, capable of encapsulating and protecting active ingredients. Indeed, drug-delivery systems are more and more developed in order to decrease the drawbacks of classical drugs (fast elimination, non-selective targeting, uncontrolled drug level in the body, etc.). In this project, drug-delivery systems have been synthetized thanks to a microfluidic device offering more efficient, reliable and reproducible results than bulk processes. Indeed, this method combines all synthesis steps in one device, allowing shorter reaction times. The flow synthesis is in addition a low-cost method, requiring few amounts of solvents and low energy devices which are promising features for a future up-scalable industrial method.


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Author

  • Schvartzman, Clémence ULiège Université de Liège > Mast. sc. chim. à fin. (FAME+)

Promotor(s)

Committee's member(s)

  • Jérôme, Christine ULiège Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)
    ORBi View his publications on ORBi
  • Lecomte, Philippe ULiège Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)
    ORBi View his publications on ORBi
  • Debuigne, Antoine ULiège Université de Liège - ULiège > Département de chimie (sciences) > Chimie des macromolécules et des matériaux organiques (CERM)
    ORBi View his publications on ORBi
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