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Faculté de Médecine
Faculté de Médecine
MASTER THESIS
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Thesis, COLLÉGIALITÉ

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Bodea, Ioana ULiège
Promotor(s) : Bakker, Julie ULiège
Date of defense : 4-Jul-2022 • Permalink : http://hdl.handle.net/2268.2/14869
Details
Title : Thesis, COLLÉGIALITÉ
Translated title : [fr] Le rôle des neurones nNOS au sein du VMHvl sur le comportement sexuel et agressif chez la souris
Author : Bodea, Ioana ULiège
Date of defense  : 4-Jul-2022
Advisor(s) : Bakker, Julie ULiège
Committee's member(s) : Franzen, Rachelle ULiège
Engel, Dominique ULiège
Parent, Anne-Simone ULiège
Language : English
Number of pages : 77
Keywords : [en] sexual behavior
[en] aggressive behavior
[en] VMHvl
[en] nNOS
Discipline(s) : Human health sciences > Multidisciplinary, general & others
Research unit : GIGA Neurosciences
Target public : Researchers
Professionals of domain
Student
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences biomédicales, à finalité spécialisée en assurance qualité
Faculty: Master thesis of the Faculté de Médecine

Abstract

[en] Nitric oxide synthase expressing neurons (nNOS) located in the ventrolateral part of the ventromedial hypothalamus (VMHvl) are known to be targeted by kisspeptin projections coming from the anteroventral periventricular nucleus (AVPV) and to be crucial for the expression of the effects of kisspeptin on female sexual behavior Moreover, nNOS knockout male mice show impaired sexual and aggressive behavior. Interestingly, VMHvl progesterone (PR) and estrogen receptor alpha (Eralpha) expressing neurons are known to regulate both aggressive and sexual behavior in mice, regardless of sex.
We hypothesize that the expression of nNOS in the VMHvl might overlap with Eralpha and PR expression. Thus, a role of VMHvl nNOS neurons on male and female aggression and sexual behavior is likely.
The aim of our study is to evaluate how the deletion of nNOS positive neurons in the VMHvl affects, social and sexual motivation as well as sexual and aggressive behaviors in both sexes.
In order to achieve that, we will use techniques such as viral infusions, stereotaxic surgery,
behavioral assessment, and immunohistochemistry.


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Author

  • Bodea, Ioana ULiège Université de Liège > Master sc. bioméd., à fin.

Promotor(s)

Committee's member(s)

  • Franzen, Rachelle ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
    ORBi View his publications on ORBi
  • Engel, Dominique ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
    ORBi View his publications on ORBi
  • Parent, Anne-Simone ULiège Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
    ORBi View his publications on ORBi
  • Total number of views 11
  • Total number of downloads 4










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