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Faculté de Médecine Vétérinaire
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Étude comparative des souches de Clostridioides difficile circulant chez l'Homme et dans la filière bovine

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Manteca Villanueva, Claire ULiège
Promotor(s) : Daube, Georges ULiège
Date of defense : 29-Jun-2023 • Permalink : http://hdl.handle.net/2268.2/17335
Details
Title : Étude comparative des souches de Clostridioides difficile circulant chez l'Homme et dans la filière bovine
Translated title : [fr] Comparative study of strains of Clostridioides difficile circulating in humans and in the bovine sector
Author : Manteca Villanueva, Claire ULiège
Date of defense  : 29-Jun-2023
Advisor(s) : Daube, Georges ULiège
Committee's member(s) : Douny, Caroline ULiège
Clinquart, Antoine ULiège
Scippo, Marie-Louise ULiège
Korsak, Nicolas ULiège
Delcenserie, V�ronique ULiège
Language : French
Number of pages : 33
Keywords : [fr] Clostridioides difficile
[fr] Antibiorésistance
[fr] zoonose
[fr] ribotypes
Discipline(s) : Life sciences > Veterinary medicine & animal health
Target public : Researchers
Professionals of domain
Student
General public
Other
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en médecine vétérinaire
Faculty: Master thesis of the Faculté de Médecine Vétérinaire

Abstract

[en] This work aims to compare the different PCR-ribotypes of Clostridioides difficile found in the bovine sector as well as in European and North American hospitals in order to draw up a geographical profile. As the PCR-ribotypes 014, 020, 027, 012 and 126 are found in humans but also in cattle, it is imaginable that these are zoonotic like the PCR-ribotypes 010 and 078 which have already been incriminated for their potential zoonotic capacity.
If the zoological aspect of C. difficile were demonstrated, humans could be contaminated in different ways, either by direct contamination and passage of bacteria from cattle to humans, or by transfer of a resistance gene.
By comparing different antibiotic resistances of the strains isolated in humans and in animals, it was concluded that the resistance to metronidazole observed in humans does not come from the bovine sector. However, Clostridioides difficile in cattle is often resistant to four other antibiotics also used in humans: clindamycin, erythromycin, moxifloxacin and tetracycline, suggesting that unreasonable use of these antibiotics in bovine medicine could be origin of antibiotic resistance in humans.


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Author

  • Manteca Villanueva, Claire ULiège Université de Liège > Master méd. vété.

Promotor(s)

Committee's member(s)

  • Douny, Caroline ULiège Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Analyse des denrées alimentaires
    ORBi View his publications on ORBi
  • Clinquart, Antoine ULiège Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Technologie des denrées alimentaires
    ORBi View his publications on ORBi
  • Scippo, Marie-Louise ULiège Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Analyse des denrées alimentaires
    ORBi View his publications on ORBi
  • Korsak, Nicolas ULiège Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Département de sciences des denrées alimentaires (DDA)
    ORBi View his publications on ORBi
  • Delcenserie, V�ronique ULiège Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Gestion de la qualité dans la chaîne alimentaire
    ORBi View his publications on ORBi
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