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Faculté des Sciences appliquées
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Development of functionalized textiles for burn treatment

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Bernard, Julie ULiège
Promotor(s) : Lambert, Stéphanie ULiège
Date of defense : 26-Jun-2023/27-Jun-2023 • Permalink : http://hdl.handle.net/2268.2/17753
Details
Title : Development of functionalized textiles for burn treatment
Translated title : [fr] Production de textiles fonctionnalisés pour le traitement de brûlures.
Author : Bernard, Julie ULiège
Date of defense  : 26-Jun-2023/27-Jun-2023
Advisor(s) : Lambert, Stéphanie ULiège
Committee's member(s) : Ruffoni, Davide ULiège
Tilkin, Rémi 
Monteiro, Ana ULiège
Language : English
Number of pages : 92
Keywords : [en] silica gels
[en] electrospinning
[en] functionalized textile
Discipline(s) : Engineering, computing & technology > Multidisciplinary, general & others
Funders : Walloon Region (Win4Collective call)
Research unit : Centexbel from Grâce-Hollogne and NCE Department of the University of Liège
Name of the research project : Projet MicroEcoTex
Target public : Other
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en ingénieur civil biomédical, à finalité spécialisée
Faculty: Master thesis of the Faculté des Sciences appliquées

Abstract

[fr] Burn wounds are particularly affected by rapid bacterial colonization leading to infection. Infection hinders the healing time resulting in longer care or diminishes recovery. Therefore a way to control the growth of the micro-organisms and thereby prevent infections is to apply a functionalized textile containing antibacterial agents to burn skin.


This thesis aims to develop an antimicrobial textile based on eco-responsible materials.
In this thesis, two strategies to incorporate the antimicrobial in a polymer matrix and to ensure a sustained release are investigated.

The first method consists in the encapsulation of the antimicrobial in porous silica gels. Silica gels present different textures depending on the precursors (i.e. TMOS, TEOS, TPOS) and the nucleating agents (i.e. EDAS, PTMS, EDAES) used. The encapsulation of an antimicrobial, Poly-L-lysine in TEOS/PTMS sample and in a silica-containing phosphate groups delivered a high percentage of encapsulation.

The second method consists in direct incorporation of the antimicrobial during electrospinning. Electrospinning is a versatile technique to generate a nanofibrous structure which has a high porosity and a high surface area to volume ratio. In this thesis, alginate and PCL electrospun nanofibers showed a fibrous morphology and structural uniformity. The diffusion of antimicrobials agents out of an alginate matrix was also investigated and showed that alginate hinders the diffusion of the Poly-L-lysine antimicrobial, while the Polymyxin B one could diffuse out the alginate matrix. A PCL matrix showed a beneficial diffusion for both of the antimicrobials.

As a result, the prospect of encapsulating Poly-L-lysine in silica gels is promising and needs further investigations about the dynamics of its release. Moreover, the prospect of integrating antimicrobials in electrospun fibres is conceivable and may be investigated in the near future.


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Author

  • Bernard, Julie ULiège Université de Liège > Master ing. civ. biomed., à fin.

Promotor(s)

Committee's member(s)

  • Ruffoni, Davide ULiège Université de Liège - ULiège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
    ORBi View his publications on ORBi
  • Tilkin, Rémi
  • Monteiro, Ana ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
    ORBi View his publications on ORBi
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