Étude de la synergie entre certains lipopeptides sur leur activité cytotoxique et leur activité antivirale

Abstract

Fengycin, surfactin and lichenysin are lipopeptides that are relatively well known for their antibacterial and antifungal activities. However, they also possess cytotoxic and antiviral activities, which were studied in this work. In addition, an analysis of the synergy developed between the lipopeptides and the action this has on their different activities was studied. It was shown that lichenysin is the most cytotoxic lipopeptide, while fengycin is the least cytotoxic. An equimolar mixture of fengycin and surfactin reduces the cytotoxicity of surfactin. However, the mixtures are all slightly more cytotoxic than fengycin alone. These results show that a synergy was developed between fengycin and surfactin. As far as antiviral activity is concerned, surfactin and lichenysin have the ability to significantly reduce the concentration of viral RNA present in a medium. However, this is strongly correlated with the fall in cell viability. A mixture of fengycin-surfactin and fengycin-lichenysin makes it possible to distinguish more clearly between the antiviral and cytotoxic activity of these lipopeptides.