The antisense protein of the human immunodeficiency virus type I contains a leucine-rich nuclear export signal
Laval, Florent
Promoteur(s) : Willems, Luc
Date de soutenance : 28-aoû-2017 • URL permanente : http://hdl.handle.net/2268.2/3100
Détails
Titre : | The antisense protein of the human immunodeficiency virus type I contains a leucine-rich nuclear export signal |
Titre traduit : | [fr] La protéine anti-sens du Virus de l'Immunodéficience Humaine de type I contient un signal d'export nucléaire riche en résidus leucine |
Auteur : | Laval, Florent |
Date de soutenance : | 28-aoû-2017 |
Promoteur(s) : | Willems, Luc |
Langue : | Anglais |
Nombre de pages : | 86 |
Mots-clés : | [en] Human Immunodeficiency Virus [en] Overlapping genes [en] Antisense protein [en] Nuclear Export Signal [en] Subcellular localization |
Discipline(s) : | Sciences du vivant > Biochimie, biophysique & biologie moléculaire |
Centre(s) de recherche : | Université du Québec À Montréal - Centre de recherche BIOMED |
Public cible : | Chercheurs Professionnels du domaine Etudiants |
Institution(s) : | Université de Liège, Liège, Belgique |
Diplôme : | Master en bioingénieur : chimie et bioindustries, à finalité spécialisée |
Faculté : | Mémoires de la Gembloux Agro-Bio Tech (GxABT) |
Résumé
[en] Acquired Immunodeficiency Syndrome (AIDS) is characterized by a substantial
alteration of the immune system caused by the Human Immunodeficiency Virus (HIV).
Numerous studies have been conducted since the emergence of this worldwide pandemic. The
ability of this virus to produce an antisense protein (ASP) was suggested a few years after its
isolation, but the existence of such a protein has been controverted for a long time. This protein
is presumably involved in several viral replication-related pivotal mechanisms and could also
play a role in viral persistence. Furthermore, as this protein is supposed to take part into
pathways occurring in both the cytoplasm and the nucleus, it was suggested that ASP can
shuttle between these two subcellular compartments. Since transport of macromolecules across
the nuclear envelope often relies on specific signals, the objective is to investigate whether ASP
possesses such a distinctive motif. Studies conducted in the context of this master’s thesis
strongly support the existence of a leucine-rich Nuclear Export Signal within this antisense
protein. Moreover, experimental data also underscore the potential involvement of cellular
proteins in this export mechanism.
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