Faculté des Sciences appliquées
Faculté des Sciences appliquées

Design of a reliable control strategy for a continuous wet granulation manufacturing unit for Oral Solid Dosage Forms

Vanherck, Rémy ULiège
Promotor(s) : Pfennig, Andreas ULiège
Date of defense : 6-Sep-2018/7-Sep-2018 • Permalink :
Title : Design of a reliable control strategy for a continuous wet granulation manufacturing unit for Oral Solid Dosage Forms
Translated title : [fr] Design d'une strategie de contrôle fiable pour une unité industrielle de granulation continue par voie humide pour formes solides
Author : Vanherck, Rémy ULiège
Date of defense  : 6-Sep-2018/7-Sep-2018
Advisor(s) : Pfennig, Andreas ULiège
Committee's member(s) : Colacino, Franco 
Léonard, Grégoire ULiège
Language : English
Discipline(s) : Engineering, computing & technology > Chemical engineering
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en ingénieur civil en chimie et science des matériaux, à finalité spécialisée
Faculty: Master thesis of the Faculté des Sciences appliquées


[fr] For my thesis, I had the opportunity to work in the Dry Forms Production department of UCB ("Union
Chimique Belge", Belgian Chemical Union).
During my stay, the company was building a new module centered around a Continuous Wet Granulation
The goal is to implement real-time release production of the drug. This means that the characteristics of the
product have to be known in real-time. UCB plans to reach this goal step by step using a "Quality by Design"
(QbD) approach for the process development. The objective of this control strategy is that the quality of the
product should be built-in by understanding the product and the process which manufactures it. Also, the
quality of the equipment used to manufacture the process should be ensured, both at the design stage and
during production.
First, the product’s "Target Product Profile" is defined. It is a list of the properties in the final product that
ensure its quality. The link between the drug’s QA and a list of possible risks is then established iteratively.
This list is first created based on theoretical knowledge and prior knowledge and then refined by making experiments.
It will be used to choose how to monitor the Critical Process Parameters (CPP) and intermediate
product Critical Quality Attributes (CQAs) which were deduced from the quality attributes. After the Critical
Process Parameters are defined, the design space is modelled from the correlation between the CPPs and
CQAs. This design space will have to be created directly from the continuous wet granulation production
line and will be used as the initial control strategy.
Also, the equipment should be designed to ensure that the quality of the product is maintained at any process
Finally, the equipment and environment should be assessed and controlled to limit any possible quality risk
to the product.



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  • Vanherck, Rémy ULiège Université de Liège > Master ingé. civil chim. & sc. mat., à fin.


Committee's member(s)

  • Colacino, Franco UCB
  • Léonard, Grégoire ULiège Université de Liège - ULiège > Department of Chemical Engineering > Intensif.des procéd. de l'indust.chim.basée sur l'anal.syst.
    ORBi View his publications on ORBi
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  • Total number of downloads 1

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