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Faculté de Médecine Vétérinaire
Faculté de Médecine Vétérinaire
MASTER THESIS
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Dialysis as a potential treatment for atypical myopathy in equids

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Jupiter, Chloé ULiège
Promotor(s) : Votion, Dominique ULiège
Date of defense : 27-Jun-2019 • Permalink : http://hdl.handle.net/2268.2/7162
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Title : Dialysis as a potential treatment for atypical myopathy in equids
Translated title : [fr] La dialyse : un traitement éventuel de la myopathie atypique des équidés
Author : Jupiter, Chloé ULiège
Date of defense  : 27-Jun-2019
Advisor(s) : Votion, Dominique ULiège
Committee's member(s) : Amory, Helene ULiège
Cesarini-Latorre, Carlota ULiège
Grulke, Sigrid ULiège
de la Rebiere de Pouyade, Geoffroy ULiège
Language : English
Number of pages : 41
Keywords : [en] Dialysis
[en] atypical myopathy
[en] hypoglycin A
Discipline(s) : Life sciences > Veterinary medicine & animal health
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en médecine vétérinaire
Faculty: Master thesis of the Faculté de Médecine Vétérinaire

Abstract

[en] Atypical myopathy is the term referring to the intoxication resulting from the ingestion of the environmental toxin, hypoglycin A. This illness, often lethal, affects grazing equids on pasture where the surroundings contain sycamore maple trees. The metabolite of hypoglycin A causes severe destruction in postural, respiratory and cardiac muscles. Hypoglycin A and its metabolite are detected in equids presenting the disease’s clinical signs. Both are eliminated by renal excretion and can be detected in the urine as well.
In both human and small animal medicine, renal replacement therapy by dialysis has been used for decades as a treatment in case of acute renal failure and various toxicities. However, few studies have investigated this subject in horses.
The investigation of the different dialysis properties and their applications to horses and atypical myopathy provide favorable elements for using dialysis in equids as well as in the treatment of atypical myopathy to eliminate the toxin and its metabolite. Complementary studies carried out on these molecules ‘properties along with an in vitro model could enable confirmation of this allegation.


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Author

  • Jupiter, Chloé ULiège Université de Liège > Master méd. vété.

Promotor(s)

Committee's member(s)

  • Amory, Helene ULiège Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
    ORBi View his publications on ORBi
  • Cesarini-Latorre, Carlota ULiège Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
    ORBi View his publications on ORBi
  • Grulke, Sigrid ULiège Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)
    ORBi View his publications on ORBi
  • de la Rebiere de Pouyade, Geoffroy ULiège Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux
    ORBi View his publications on ORBi
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