Master's Thesis : Tailored hydroxyapatite for bone reconstruction
Idczak, Gaëlle
Promoteur(s) : Grandfils, Christian ; Lambert, Stéphanie
Date de soutenance : 25-jui-2020/26-jui-2020 • URL permanente : http://hdl.handle.net/2268.2/9030
Détails
Titre : | Master's Thesis : Tailored hydroxyapatite for bone reconstruction |
Titre traduit : | [fr] Contrôle de la synthèse de l'hydroxyapatite pour la reconstruction osseuse |
Auteur : | Idczak, Gaëlle |
Date de soutenance : | 25-jui-2020/26-jui-2020 |
Promoteur(s) : | Grandfils, Christian
Lambert, Stéphanie |
Membre(s) du jury : | Ruffoni, Davide
GILLET, Philippe |
Langue : | Anglais |
Nombre de pages : | 86 |
Mots-clés : | [en] hydroxyapatite [en] CTAB [en] DLS [en] wet method |
Discipline(s) : | Ingénierie, informatique & technologie > Multidisciplinaire, généralités & autres |
Centre(s) de recherche : | CEIB, NCE |
Institution(s) : | Université de Liège, Liège, Belgique |
Diplôme : | Master en ingénieur civil biomédical, à finalité spécialisée |
Faculté : | Mémoires de la Faculté des Sciences appliquées |
Résumé
[en] Hydroxyapatite (HA), Ca5(PO4)3(OH), is a bioceramic well-known in the biomaterial
field. Through the last decades, efforts have been particularly developed in the
synthesis of nanostructured hydroxyapatite and in the control of its properties, mainly
to increase its specific surface area. In order to achieve that, surfactants acting as
template during synthesis represent a promising research field. However, no study
depicts clearly the behaviour of surfactants in the conditions of HA synthesis, as well
as the effect of surfactant concentration on the structure of hydroxyapatite.
The goal of this work is to study the behaviour of a cationic surfactant, cetrimonium
bromide (CTAB), in conditions of HA synthesis (pH 10.5 and presence of phosphate
ions) and to perform HA synthesis with CTAB. To achieve that, different CTAB
concentrations ranging from 0.4 to 100 mmol/L were analysed through Dynamic light
scattering (DLS) at temperatures of 25 and 50 °C. Results showed that temperature
does not impact significantly the CTAB micelles behaviour. Moreover, CTAB forms
aggregates at concentrations lower than 10 mmol/L. These aggregates tend to
disappear when CTAB concentration increases and unimodal size micelles are
formed.
HA syntheses were performed using appropriate CTAB concentrations determined by
means of DLS results. After synthesis, HA powders have been characterized by
FT-IR, TGA, XRD, BET and TEM techniques and have been compared to
commercialized HA powder. It is observed that surface area can be undoubtedly
increased (up to 150 m²/g) by the use of CTAB surfactant. Moreover, morphology
and size of HA particles are impacted by CTAB concentrations.
These results are promising and show the importance of surfactant behaviour's
comprehension in HA synthesis. This opens new perspectives in the biomaterials
domains and especially in bone reconstruction.
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