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Faculté de Médecine Vétérinaire
Faculté de Médecine Vétérinaire
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Heredity of patent ductus arteriosus in dogs

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Roudeau, Oriane ULiège
Promotor(s) : Grobet, Luc ULiège
Date of defense : 2-Jul-2020 • Permalink : http://hdl.handle.net/2268.2/9553
Details
Title : Heredity of patent ductus arteriosus in dogs
Translated title : [fr] L'hérédité de la persistance du canal artériel chez le chien
Author : Roudeau, Oriane ULiège
Date of defense  : 2-Jul-2020
Advisor(s) : Grobet, Luc ULiège
Committee's member(s) : Gabriel, Annick ULiège
Dubois, Axel ULiège
Dourcy, Mickael ULiège
Vandenput, Sandrina ULiège
Jauniaux, Thierry ULiège
Language : English
Number of pages : 28
Keywords : [en] patent ductus arterisous
[en] dog
[en] heredity
[en] inheritance
[en] breed
Discipline(s) : Life sciences > Veterinary medicine & animal health
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en médecine vétérinaire
Faculty: Master thesis of the Faculté de Médecine Vétérinaire

Abstract

[en] Background: Patent ductus arteriosus (PDA) is the most common cardiac congenital malformation in dogs. Screenings of the affected dogs highlight recurrent breeds, strongly suggesting genetic disorders to be the cause of said defect. The pathophysiological process is well known and the treatment keeps being developed with high-end devices, however the question of transmission is still unclear. Therefore genetic detecting tests are not even discussed yet.

Objectives: The first purpose of this synthesis is to reveal the genetic component of PDA by finding dogs' bloodlines (breeds and families) in which the defect is considerably present. Furthermore, an accurate description of the ductal closure mechanism at the molecular and genetic levels will lead to genes which can then be investigated for potential mutations. A highlight of those involved genes represents the second objective.

Methods: The literature has been mostly reviewed in Pubmed database and the OMIA website (Online Mendelian Inheritance in Animals). Data have been gathered and interpreted to attempt to identify the genetic origin of PDA.

Results: Females and purebred dogs, especially German Shepherd and small breeds such as Pomeranian, Miniature Poodle, Bichon Frise and Chihuhua are the most affected by PDA. It is also found in some families and in case of inbreeding across generations. The pathology occurs when the balance between relaxation and contraction of the VSMCs (Vascular Smooth Muscle Cells) is jeopardized.

Key words: patent ductus arteriosus, genetic/inheritance, dog, breed


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Author

  • Roudeau, Oriane ULiège Université de Liège > Master méd. vété.

Promotor(s)

Committee's member(s)

  • Gabriel, Annick ULiège Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques
    ORBi View his publications on ORBi
  • Dubois, Axel ULiège Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies
    ORBi View his publications on ORBi
  • Dourcy, Mickael ULiège Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques
    ORBi View his publications on ORBi
  • Vandenput, Sandrina ULiège Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
    ORBi View his publications on ORBi
  • Jauniaux, Thierry ULiège Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Département de morphologie et pathologie (DMP)
    ORBi View his publications on ORBi
  • Total number of views 206
  • Total number of downloads 801










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