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Faculté de Médecine
Faculté de Médecine
MASTER THESIS
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Evaluation of the neovascularisation of 3D-printed hydroxyapatite implants in rats

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Desonniaux, Marie ULiège
Promotor(s) : Cobraiville, Elisabeth
Date of defense : 6-Sep-2021 • Permalink : http://hdl.handle.net/2268.2/12878
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Title : Evaluation of the neovascularisation of 3D-printed hydroxyapatite implants in rats
Translated title : [fr] évaluation de la néovascularisation des implant imprimé en 3D chez le rat
Author : Desonniaux, Marie ULiège
Date of defense  : 6-Sep-2021
Advisor(s) : Cobraiville, Elisabeth 
Committee's member(s) : Nolens, Grégory 
RONSMANS, Christophe ULiège
Stordeur, Philippe 
Language : English
Number of pages : 59
Discipline(s) : Life sciences > Biotechnology
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences biomédicales, à finalité approfondie
Faculty: Master thesis of the Faculté de Médecine

Abstract

[en] Introduction: Maxillo-facial defects are a commonly encountered problem that cranio-facial and plastic surgeons have to face in hospital practice. It can have either a pathologic or a non-pathologic origin. The current gold standard for bone replacement for in those defects is an autograft from a fibula free flap. However, the current gold standard has limitations and synthetic bone replacement overcoming those limitations have known an expansion in the recent years.
Objective: Two main objectives were pursued during this master thesis. The first one was to develop and evaluate the design of the sub-scapular implant as well as the surgical implantation protocol. The second was to develop and evaluate the imaging protocols to visualise the neovascularisation inside the implant.
Methods: First a cadaver test was realised to test and evaluate the design of the implant as well as the surgical implantation technique. Secondly, a pilot study was realised in a small group of 5 rats. During this pilot study, the surgical technique was adapted and the vascularisation was evaluated by micro-CT. Both in-vivo and ex-vivo micro-CT were used.
Results: The design medium rectangular L was the design the most fitting regarding size and implan- tation incision closure. The tail catheter injection technique was chosen over the needle injection. The in-vivo micro-CT show vascularisation only on the outside of implant. The pre-test ex-vivo micro-CT shown vascularisation inside organs.
Conclusion: The medium rectangular L design was chosen to be implanted in the rats of the pilot study. The placement of the medium rectangular L at the interscapular area in rats with the chosen protocol was successful. The vascularisation surrounding the implant can be seen with the in-vivo micro-CT. However, the neovascularisation inside the implant could not be seen with that imaging method.


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Author

  • Desonniaux, Marie ULiège Université de Liège > Master sc. bioméd., à fin.

Promotor(s)

Committee's member(s)

  • Nolens, Grégory
  • RONSMANS, Christophe ULiège Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de chirurgie plastique et maxillo-faciale
    ORBi View his publications on ORBi
  • Stordeur, Philippe
  • Total number of views 34
  • Total number of downloads 0










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