Master Thesis Online
Thesis, COLLÉGIALITÉ
El Karouni, Walid 
Promotor(s) :
Sakalihasan, Natzi
Date of defense : 5-Jul-2022 • Permalink : http://hdl.handle.net/2268.2/14858
Mémoire Walid El Karouni s164277.pdfDetails
| Title : | Thesis, COLLÉGIALITÉ |
| Translated title : | [fr] Anévrisme de l'aorte abdominale et cancer |
| Author : | El Karouni, Walid
|
| Date of defense : | 5-Jul-2022 |
| Advisor(s) : | Sakalihasan, Natzi
|
| Committee's member(s) : | Colige, Alain
DURIEUX, Rodolphe
Struman, Ingrid
|
| Language : | English |
| Number of pages : | 51 |
| Keywords : | [en] Biomarker [fr] Micro-RNA [fr] Abdominal aortic aneurysm [fr] Cancer |
| Discipline(s) : | Human health sciences > Oncology Human health sciences > Cardiovascular & respiratory systems |
| Target public : | Researchers Professionals of domain Student |
| Institution(s) : | Université de Liège, Liège, Belgique |
| Degree: | Master en sciences biomédicales, à finalité approfondie |
| Faculty: | Master thesis of the Faculté de Médecine |
Abstract
[en] Multiple clinical trials have indicated that cancer, rather than cardiovascular illnesses, was the leading cause of death in follow-up examinations of abdominal aortic aneurysm (AAA) patients that underwent repair surgery. Also, inflammation, having a prominent role in AAA disease, has been proven to play an important role in cancer development. Therefore, a potential link could be made between AAA and cancer. We searched for micro-RNA (miRNA) candidate biomarker(s) in plasma of 15 AAA patients that developed cancer and 15 that did not. Hsa-miR-122-5p was found significantly upregulated in cancer patients compared to non-cancer patients. Further studies need to be done in order to confirm its role on bigger cohorts and to establish it as a possible therapeutic target.
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