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Faculté de Médecine
Faculté de Médecine
MASTER THESIS
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Thesis, COLLÉGIALITÉ

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El Karouni, Walid ULiège
Promotor(s) : Sakalihasan, Natzi ULiège
Date of defense : 5-Jul-2022 • Permalink : http://hdl.handle.net/2268.2/14858
Details
Title : Thesis, COLLÉGIALITÉ
Translated title : [fr] Anévrisme de l'aorte abdominale et cancer
Author : El Karouni, Walid ULiège
Date of defense  : 5-Jul-2022
Advisor(s) : Sakalihasan, Natzi ULiège
Committee's member(s) : Colige, Alain ULiège
DURIEUX, Rodolphe ULiège
Struman, Ingrid ULiège
Language : English
Number of pages : 51
Keywords : [en] Biomarker
[fr] Micro-RNA
[fr] Abdominal aortic aneurysm
[fr] Cancer
Discipline(s) : Human health sciences > Oncology
Human health sciences > Cardiovascular & respiratory systems
Target public : Researchers
Professionals of domain
Student
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences biomédicales, à finalité approfondie
Faculty: Master thesis of the Faculté de Médecine

Abstract

[en] Multiple clinical trials have indicated that cancer, rather than cardiovascular illnesses, was the leading cause of death in follow-up examinations of abdominal aortic aneurysm (AAA) patients that underwent repair surgery. Also, inflammation, having a prominent role in AAA disease, has been proven to play an important role in cancer development. Therefore, a potential link could be made between AAA and cancer. We searched for micro-RNA (miRNA) candidate biomarker(s) in plasma of 15 AAA patients that developed cancer and 15 that did not. Hsa-miR-122-5p was found significantly upregulated in cancer patients compared to non-cancer patients. Further studies need to be done in order to confirm its role on bigger cohorts and to establish it as a possible therapeutic target.


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Author

  • El Karouni, Walid ULiège Université de Liège > Master sc. bioméd., à fin.

Promotor(s)

Committee's member(s)

  • Colige, Alain ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
    ORBi View his publications on ORBi
  • DURIEUX, Rodolphe ULiège Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de chirurgie cardio-vasculaire et thoracique
    ORBi View his publications on ORBi
  • Struman, Ingrid ULiège Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
    ORBi View his publications on ORBi
  • Total number of views 66
  • Total number of downloads 76










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