Faculté de Médecine
Faculté de Médecine


Mouziane, Loubna ULiège
Promotor(s) : Gomes da Silva, Carla ; Delacroix, Laurence ULiège
Date of defense : 4-Sep-2023 • Permalink :
Title : Thesis, COLLÉGIALITÉ
Author : Mouziane, Loubna ULiège
Date of defense  : 4-Sep-2023
Advisor(s) : Gomes da Silva, Carla 
Delacroix, Laurence ULiège
Committee's member(s) : Seutin, Vincent ULiège
Stoufflet, Julie ULiège
PARENT, Anne-Simone ULiège
Language : English
Discipline(s) : Life sciences > Biochemistry, biophysics & molecular biology
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences biomédicales, à finalité approfondie
Faculty: Master thesis of the Faculté de Médecine


[en] Cortical interneurons are cardinal for the correct function of neocortical circuits. A disruption in their neurogenesis, migration, connectivity or circuit maturation might lead to important consequences on the fine excitation-inhibition balance and the debut of developmental disorders such as autism spectrum disorder, epilepsy and schizophrenia. Cortical interneurons are born in the ventral forebrain and interneuron migration is a limiting step for cell integration into the cortical layer and the establishment of neuronal circuits. It is therefore crucial to understand the specific mechanisms of guidance to the cortex.
A recent publication shed light on the important role of first-wave oligodendrocyte precursor cells (OPCs) as a support for the migration of interneurons, concomitantly travelling across the cortex. In fact, OPCs perform unidirectional contact repulsion with interneurons mediated by the interaction of semaphorin 6a and plexin A3 receptors to impede their adherence to blood vessels, which release the chemokine Cxcl12. Complete depletion of the first-wave OPCs induced a decrease in the number of interneurons in the cortical wall and their accumulation in the ventral subventricular zone, suggesting the important consequence of this interaction on interneuron speed migration.
The goal of this work is to explore the fine mechanisms of interneuron-OPC interaction by preventing the expression of semaphorin 6a and CXCR4 receptor, thereby interfering with their response to Cxcl12. By selectively impairing these signalling pathways we will be able to assert their exclusive role and investigate the post-natal sequelae of interneuron delay in migration.



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  • Mouziane, Loubna ULiège Université de Liège > Master sc. bioméd., à fin.


Committee's member(s)

  • Seutin, Vincent ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
    ORBi View his publications on ORBi
  • Stoufflet, Julie ULiège Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
    ORBi View his publications on ORBi
  • PARENT, Anne-Simone ULiège Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Centre de l'obésité de l'enfant - adolescent
    ORBi View his publications on ORBi
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