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Mémoire, Partim B

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Cabrera-Tejera, Bastien ULiège
Promotor(s) : Eppe, Gauthier ULiège
Date of defense : 22-Jan-2024 • Permalink : http://hdl.handle.net/2268.2/20028
Details
Title : Mémoire, Partim B
Translated title : [fr] Optimisation de nanosubstrats en silicium poreux pour des applications en LDI-MS : Etude systématique de l'impact des paramètres morphologiques
Author : Cabrera-Tejera, Bastien ULiège
Date of defense  : 22-Jan-2024
Advisor(s) : Eppe, Gauthier ULiège
Committee's member(s) : Müller, Wendy ULiège
Leyh, Bernard ULiège
Coffinier, Yannick 
Language : English
Number of pages : 111
Keywords : [en] Mass spectrometry
[en] MS
[en] SALDI-MS
[en] MALDI-MS
[en] LDI
[en] Porous silicon
[en] Effective Temperature
Discipline(s) : Physical, chemical, mathematical & earth Sciences > Chemistry
Target public : Researchers
Professionals of domain
Student
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences chimiques, à finalité approfondie
Faculty: Master thesis of the Faculté des Sciences

Abstract

[en] Laser desorption/ionization (LDI) mass spectrometry on porous silicon (MS) is a promising alternative to matrix-assisted laser desorption/ionization (MALDI) MS for the study of small molecules. Indeed, LDI-MS employs nanostructured porous silicon surfaces instead of organic matrices to assist the analyte desorption/ionization, which greatly limits the interference generated in the low m/z range, and thus allows the analysis of low molecular weight compounds. In addition, the use of porous silicon surface has the potential to provide other valuable advantages, such as the dual-polarity capabilities of the substrate, the compatibility with multimodal experiments and the possibility to functionalize the surface to improve the selectivity or the limit of detection of the technique. However, the use of porous silicon surfaces in real applications first requires a good understanding of the different aspects of the LDI-MS technique, including for example the impact of the nanosubstrate morphology on the desorption/ionization process harshness (analytes fragmentation). The objective of this Master’s thesis is to gain a better understanding of the desorption/ionization process occurring on porous silicon surfaces to ultimately optimize them for the LDI-MS analysis of small molecules such as metabolites or organic pollutants.


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Author

  • Cabrera-Tejera, Bastien ULiège Université de Liège > Master en sc. chimiques, fin. approf.

Promotor(s)

Committee's member(s)

  • Müller, Wendy ULiège Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique
    ORBi View his publications on ORBi
  • Leyh, Bernard ULiège Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de dynamique moléculaire
    ORBi View his publications on ORBi
  • Coffinier, Yannick Université de Lille
  • Total number of views 15
  • Total number of downloads 2










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