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Faculté des Sciences
Faculté des Sciences
MASTER THESIS
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Development of innovative strategies for the preparation and purification of Ketamine

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Collin, Diégo ULiège
Promotor(s) : Monbaliu, Jean-Christophe ULiège ; Leyssens, Tom
Date of defense : 26-Jun-2017 • Permalink : http://hdl.handle.net/2268.2/2473
Details
Title : Development of innovative strategies for the preparation and purification of Ketamine
Translated title : [fr] Développement de nouvelles stratégies pour la synthèse et la purification de la Ketamine
Author : Collin, Diégo ULiège
Date of defense  : 26-Jun-2017
Advisor(s) : Monbaliu, Jean-Christophe ULiège
Leyssens, Tom 
Committee's member(s) : Monbaliu, Jean-Christophe ULiège
Damblon, Christian ULiège
Leyssens, Tom 
Provins, Laurent 
Language : English
Number of pages : 75
Keywords : [en] Ketamine
[en] active pharmaceutical ingredient,
[en] Innovative strategies
[en] flow chemistry
[en] purification
Discipline(s) : Physical, chemical, mathematical & earth Sciences > Chemistry
Funders : Center for Integrated Technology and Organic Synthesis (CiTOS)
Research unit : Center for Integrated Technology and Organic Synthesis (CiTOS)
Name of the research project : Development of innovative strategies for the preparation and purification of Ketamine
Target public : Researchers
Professionals of domain
Student
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en sciences chimiques, à finalité approfondie
Faculty: Master thesis of the Faculté des Sciences

Abstract

[en] Racemic ketamine receives breakthrough therapy designation for major depressive disorder with imminent risk for suicide, from the US Food and Drug Administration. (R,S)-Ketamine was synthesized in 1962 by the American chemist, Calvin Lee Stevens. Until to date, this pharmaceutical product was used as anesthétique in the medicinal field. Racemic ketamine is synthesized according 4 general steps under batch conditions. However, the poor efficiency and flexibility of batch processes is one out of several factors leading to drug shortages reported by the FDA. In this research, we showed the investigation of racemic ketamine synthesis in order to develop innovative strategies for the preparation under continuous-flow process and purification of racemic ketamine by crystallization process.


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Author

  • Collin, Diégo ULiège Université de Liège > Master en sc. chimiques, à fin.

Promotor(s)

Committee's member(s)

  • Monbaliu, Jean-Christophe ULiège Université de Liège - ULg > Département de chimie (sciences) > Chimie organométallique et catalyse homogène
    ORBi View his publications on ORBi
  • Damblon, Christian ULiège Université de Liège - ULg > Département de chimie (sciences) > Chimie biologique structurale
    ORBi View his publications on ORBi
  • Leyssens, Tom
  • Provins, Laurent
  • Total number of views 201
  • Total number of downloads 8










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