Master Thesis Online
Thesis, FRANZEN Rachelle
Vanleyssem, Raphaël 
Promotor(s) :
Close, Pierre
Date of defense : 1-Jul-2026 • Permalink : http://hdl.handle.net/2268.2/25980
VANLEYSSEM-Mémoire.pdfDetails
| Title : | Thesis, FRANZEN Rachelle |
| Translated title : | [fr] Les modifications des ARNt dépendantes d’ELP3 façonnent la réponse immunitaire médiée par le CMH‑II dans le PDAC |
| Author : | Vanleyssem, Raphaël
|
| Date of defense : | 1-Jul-2026 |
| Advisor(s) : | Close, Pierre
|
| Committee's member(s) : | Herfs, Michael
Ehx, Grégory
Jacobs, Nathalie
|
| Language : | English |
| Number of pages : | 75 |
| Keywords : | [en] Translation [en] tRNA modifications [en] PDAC [en] Immunology [en] Immunotherapy |
| Discipline(s) : | Human health sciences > Oncology |
| Research unit : | GIGA Cancer |
| Target public : | Researchers Professionals of domain Student |
| Institution(s) : | Université de Liège, Liège, Belgique |
| Degree: | Master en sciences biomédicales, à finalité approfondie |
| Faculty: | Master thesis of the Faculté de Médecine |
Abstract
[en] Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, driven by profound immunosuppression and a highly resistant tumor microenvironment. This thesis explores whether regulating tRNA modifications through ELP3 loss can reshape antigen presentation and enhance anti‑tumor immunity. Building on previous findings, I investigated how ELP3 deletion affects PDAC cell behavior, tumor development, and interactions with the immune system, including the characterization of major immune‑cell populations. I examined the accumulation and processing of U34‑derived protein aggregates, and the resulting modulation of MHC‑II expression and IFN‑γ responsiveness. Together, this work highlights how altering tRNA‑modification pathways can influence antigen presentation in PDAC and may offer new avenues to stimulate CD4⁺ T‑cell-mediated anti‑tumor responses.
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