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Faculté des Sciences appliquées
Faculté des Sciences appliquées
MASTER THESIS
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Master's Thesis : Tailored hydroxyapatite for bone reconstruction

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Idczak, Gaëlle ULiège
Promotor(s) : Grandfils, Christian ULiège ; Lambert, Stéphanie ULiège
Date of defense : 25-Jun-2020/26-Jun-2020 • Permalink : http://hdl.handle.net/2268.2/9030
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Title : Master's Thesis : Tailored hydroxyapatite for bone reconstruction
Translated title : [fr] Contrôle de la synthèse de l'hydroxyapatite pour la reconstruction osseuse
Author : Idczak, Gaëlle ULiège
Date of defense  : 25-Jun-2020/26-Jun-2020
Advisor(s) : Grandfils, Christian ULiège
Lambert, Stéphanie ULiège
Committee's member(s) : Ruffoni, Davide ULiège
GILLET, Philippe ULiège
Language : English
Number of pages : 86
Keywords : [en] hydroxyapatite
[en] CTAB
[en] DLS
[en] wet method
Discipline(s) : Engineering, computing & technology > Multidisciplinary, general & others
Research unit : CEIB, NCE
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en ingénieur civil biomédical, à finalité spécialisée
Faculty: Master thesis of the Faculté des Sciences appliquées

Abstract

[en] Hydroxyapatite (HA), Ca5(PO4)3(OH), is a bioceramic well-known in the biomaterial
field. Through the last decades, efforts have been particularly developed in the
synthesis of nanostructured hydroxyapatite and in the control of its properties, mainly
to increase its specific surface area. In order to achieve that, surfactants acting as
template during synthesis represent a promising research field. However, no study
depicts clearly the behaviour of surfactants in the conditions of HA synthesis, as well
as the effect of surfactant concentration on the structure of hydroxyapatite.
The goal of this work is to study the behaviour of a cationic surfactant, cetrimonium
bromide (CTAB), in conditions of HA synthesis (pH 10.5 and presence of phosphate
ions) and to perform HA synthesis with CTAB. To achieve that, different CTAB
concentrations ranging from 0.4 to 100 mmol/L were analysed through Dynamic light
scattering (DLS) at temperatures of 25 and 50 °C. Results showed that temperature
does not impact significantly the CTAB micelles behaviour. Moreover, CTAB forms
aggregates at concentrations lower than 10 mmol/L. These aggregates tend to
disappear when CTAB concentration increases and unimodal size micelles are
formed.
HA syntheses were performed using appropriate CTAB concentrations determined by
means of DLS results. After synthesis, HA powders have been characterized by
FT-IR, TGA, XRD, BET and TEM techniques and have been compared to
commercialized HA powder. It is observed that surface area can be undoubtedly
increased (up to 150 m²/g) by the use of CTAB surfactant. Moreover, morphology
and size of HA particles are impacted by CTAB concentrations.
These results are promising and show the importance of surfactant behaviour's
comprehension in HA synthesis. This opens new perspectives in the biomaterials
domains and especially in bone reconstruction.


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Author

  • Idczak, Gaëlle ULiège Université de Liège > Master ing. civ. biomed., à fin.

Promotor(s)

Committee's member(s)

  • Ruffoni, Davide ULiège Université de Liège - ULiège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
    ORBi View his publications on ORBi
  • GILLET, Philippe ULiège Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de chirurgie de l'appareil locomoteur
    ORBi View his publications on ORBi
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