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Data-driven Inference of a TF-regulated Metabolic Network for photosynthetic organism modelling: Chlamydomonas Reinhardtii.

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Waterplas, Dries ULiège
Promotor(s) : Meyer, Patrick ULiège
Date of defense : 7-Sep-2018 • Permalink : http://hdl.handle.net/2268.2/5438
Details
Title : Data-driven Inference of a TF-regulated Metabolic Network for photosynthetic organism modelling: Chlamydomonas Reinhardtii.
Translated title : [fr] Inférence d'un réseau métaboliques sous régulation de TF pour la modélisation d'organismes photosynthétiques: Chlamydomoans Reinhardtii
Author : Waterplas, Dries ULiège
Date of defense  : 7-Sep-2018
Advisor(s) : Meyer, Patrick ULiège
Committee's member(s) : Baurain, Denis ULiège
Farnir, Frédéric ULiège
Cardol, Pierre ULiège
Language : English
Number of pages : 74
Keywords : [fr] Chlamydomonas Reinhardtii Metabolic Network Constraint-Based Modelling Transcriptomic Regulation
Discipline(s) : Life sciences > Biochemistry, biophysics & molecular biology
Research unit : BioSys : Bioinformatics and Systems Biology Lab
Name of the research project : Improving metabolic models of photosynthetic organisms using regulation from TRN-Inference
Target public : Researchers
Professionals of domain
Student
Institution(s) : Université de Liège, Liège, Belgique
Degree: Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bioinformatique et modélisation
Faculty: Master thesis of the Faculté des Sciences

Abstract

[fr] Metabolic pathways involved in photosynthesis and biosynthesis of lipids, hydrogen or growth are typically regulated by complex interdependent mechanisms involving multiple fronts of omics (genomics, transcriptomics, proteomics, …). Here, we apply Constraint-Based Modelling (CBM) techniques on a genome-scale metabolic network reconstruction of C. reinhardtii, and improve the model by integrating constraints from a Transcriptional Regulation Network, thus taking into account cell gene expression shifts under envrionmental changes.


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Author

  • Waterplas, Dries ULiège Université de Liège > Master bioch. & biol. mol. & cel., à fin.

Promotor(s)

Committee's member(s)

  • Baurain, Denis ULiège Université de Liège - ULiège > Département des sciences de la vie > Phylogénomique des eucaryotes
    ORBi View his publications on ORBi
  • Farnir, Frédéric ULiège Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Biostatistiques et bioinformatique appliquées aux sc. vétér.
    ORBi View his publications on ORBi
  • Cardol, Pierre ULiège Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues
    ORBi View his publications on ORBi
  • Total number of views 46
  • Total number of downloads 108










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